Detection of acute tubular necrosis using blood oxygenation level-dependent (BOLD) MRI
- \(\it Background/Aims:\) To date, there is no imaging technique to assess tubular function in vivo. Blood oxygen level-dependent magnetic resonance imaging (BOLD MRI) measures tissue oxygenation based on the transverse relaxation rate (R2*). The present study investigates whether BOLD MRI can assess tubular function using a tubule-specific pharmacological maneuver. \(\it Methods:\) Cross sectional study with 28 participants including 9 subjects with ATNinduced acute kidney injury (AKI), 9 healthy controls, and 10 subjects with nephron sparing tumor resection (NSS) with clamping of the renal artery serving as a model of ischemia/reperfusion (I/R)-induced subclinical ATN (median clamping time 15 min, no significant decrease of eGFR, p=0.14). BOLD MRI was performed before and 5, 7, and 10 min after intravenous administration of 40 mg furosemide. \(\it Results:\) Urinary neutrophil gelatinaseassociated lipocalin was significantly higher in ATN-induced AKI and NSS subjects than in healthy controls (p=0.03 and p=0.01, respectively). Before administration of furosemide, absolute medullary R2*, cortical R2*, and medullary/cortical R2* ratio did not significantly differ between ATN-induced AKI vs. healthy controls and between NSS-I/R vs. contralateral healthy kidneys (p>0.05 each). Furosemide led to a significant decrease in the medullary and cortical R2* of healthy subjects and NSS contralateral kidneys (p<0.05 each), whereas there was no significant change of R2* in ATN-induced AKI and the NSS-I/R kidneys (p>0.05 each). \(\it Conclusion:\) BOLD-MRI is able to detect even mild tubular injury but necessitates a tubulespecific pharmacological maneuver, e.g. blocking the Na\(^{+}\)-K\(^{+}\)-2Cl- transporter by furosemide.
Author: | Frederic BauerGND, Jan WaldGND, Felix Jan BauerGND, Lisa DahlkampGND, Felix Sebastian SeibertORCiDGND, Nikolaos PagonasGND, Egbert GedatGND, Nina BabelORCiDGND, Walter ZidekGND, Christian von BodmanGND, Joachim NoldusGND, Dieter LiermannGND, Timm WesthoffORCiDGND |
---|---|
URN: | urn:nbn:de:hbz:294-62771 |
DOI: | https://doi.org/10.1159/000485600 |
Parent Title (English): | Kidney & blood pressure research |
Document Type: | Article |
Language: | English |
Date of Publication (online): | 2019/02/14 |
Date of first Publication: | 2017/12/04 |
Publishing Institution: | Ruhr-Universität Bochum, Universitätsbibliothek |
Tag: | Open Access Fonds Acute kidney injury; BOLD; Ischemia-reperfusion injury; Kidney; MRI |
Volume: | 42 |
Issue: | 6 |
First Page: | 1078 |
Last Page: | 1089 |
Note: | Dieser Beitrag ist aufgrund einer nationalen Lizenz frei zugänglich. |
Institutes/Facilities: | Marienhospital Herne, Medizinische Klinik I |
Dewey Decimal Classification: | Technik, Medizin, angewandte Wissenschaften / Medizin, Gesundheit |
open_access (DINI-Set): | open_access |
faculties: | Medizinische Fakultät |
Licence (German): | Nationale Lizenz |