Glancing-angle deposition of nanostructures on an implant material surface
- Cell-compatible and antibacterial surfaces are needed for implants, which frequently have complex and rough surfaces. Bio-inspired columnar nanostructures can be grown on flat substrates; however, the application of these nanostructures on clinically relevant, complex, and rough surfaces was pending. Therefore, a titanium plasma spray (TPS) implant surface was coated with titanium nano-spikes via glancing angle magnetron sputter deposition (GLAD) at room temperature. Using GLAD, it was possible to cover the three-dimensional, highly structured macroscopic surface (including cavities, niches, clefts, and curved areas) of the TPS homogeneously with nano-spikes (TPS+), creating a cell-compatible and antibacterial surface. The adherence and spreading of mesenchymal stem cells (MSC) were similar for TPS and TPS+ surfaces. However, MSC adherent to TPS+ expressed less and shorter pseudopodia. The induced osteogenic response of MSC was significantly increased in cells cultivated on TPS+ compared with TPS. In addition, Gram-negative bacteria \(\textit {(E. coli)}\) adherent to the nano-spikes were partly destructed by a physico-mechanical mechanism; however, Gram-positive bacteria \(\textit {(S. aureus)}\) were not significantly damaged.
Author: | Nadine ZieglerGND, Christina SengstockGND, Viola MaiGND, Thomas Armin SchildhauerORCiDGND, Manfred KöllerGND, Alfred LudwigORCiDGND |
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URN: | urn:nbn:de:hbz:294-67692 |
DOI: | https://doi.org/10.3390/nano9010060 |
Parent Title (English): | Nanomaterials |
Publisher: | MDPI |
Place of publication: | Basel |
Document Type: | Article |
Language: | English |
Date of Publication (online): | 2019/11/28 |
Date of first Publication: | 2019/01/04 |
Publishing Institution: | Ruhr-Universität Bochum, Universitätsbibliothek |
Tag: | antibacterial effect; cell compatibility; glancing angle deposition; nanostructures; sputtering |
Volume: | 9 |
Issue: | 1 |
First Page: | 60-1 |
Last Page: | 60-11 |
Institutes/Facilities: | Lehrstuhl Werkstoffe der Mikrotechnik |
Research Department Plasmas with Complex Interactions | |
Materials Research Department | |
Research Department Closed Carbon Cycle Economy | |
Institut für Werkstoffe, Lehrstuhl Werkstoffwissenschaft | |
open_access (DINI-Set): | open_access |
faculties: | Fakultät für Maschinenbau |
Licence (English): | Creative Commons - CC BY 4.0 - Attribution 4.0 International |