CSF diagnostics
- Cerebrospinal fluid (CSF) diagnostics has emerged as a valid tool for a variety of neurological diseases. However, CSF diagnostics has been playing a subordinate role in the diagnosis of many neurological conditions. Thus, in the multitude of neuromuscular diseases in which motor neurons are affected, a CSF sample is rarely taken routinely. However, CSF diagnostics has the potential to specify the diagnosis and monitor the treatment of neuromuscular disorders. In this review, we therefore focused on a variety of neuromuscular diseases, among them amyotrophic lateral sclerosis (ALS), peripheral neuropathies, and spinal muscular atrophy (SMA), for which CSF diagnostics has emerged as a promising option for determining the disease itself and its progression. We focus on potentially valuable biomarkers among different disorders, such as neurofilaments, cytokines, other proteins, and lipids to determine their suitability, differentiating between different neurological disorders and their potential to determine early disease onset, disease progression, and treatment outcome. We further recommend novel approaches, e.g., the use of mass spectrometry as a promising alternative techniques to standard ELISA assays, potentially enhancing biomarker significance in clinical applications.
Author: | Karsten KrauseGND, Maximilian WulfORCiDGND, Paula SommerGND, Katalin BarkovitsORCiDGND, Matthias VorgerdORCiDGND, Katrin Marcus-AlicORCiDGND, Britta EggersORCiDGND |
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URN: | urn:nbn:de:hbz:294-85270 |
DOI: | https://doi.org/10.3390/diagnostics11091522 |
Parent Title (English): | Diagnostics |
Subtitle (English): | a potentially valuable tool in neurodegenerative and inflammatory disorders involving motor neurons; a review |
Publisher: | MDPI |
Place of publication: | Basel |
Document Type: | Article |
Language: | English |
Date of Publication (online): | 2022/01/13 |
Date of first Publication: | 2021/08/24 |
Publishing Institution: | Ruhr-Universität Bochum, Universitätsbibliothek |
Tag: | ELISA; Guillain-Barré syndrome; amyotrophic lateral sclerosis; biomarker; cerebrospinal fluid; motor neurons; peripheral neuropathies; spinal muscular atrophy |
Volume: | 11 |
Issue: | 9, Article 1522 |
First Page: | 1522-1 |
Last Page: | 1522-32 |
Institutes/Facilities: | Medizinisches Proteom-Center |
Zentrum für Protein-Diagnostik (PRODI) | |
open_access (DINI-Set): | open_access |
faculties: | Medizinische Fakultät |
Licence (English): | Creative Commons - CC BY 4.0 - Attribution 4.0 International |