- Patients with end-stage renal disease (ESRD) suffer from a progressively increasing low-grade systemic inflammation, which is associated with higher morbidity and mortality. Regulatory T cells (Tregs) play an important role in regulation of the inflammatory process. Previously, it has been demonstrated that short-chain fatty acids reduce inflammation in the central nervous system in a murine model of multiple sclerosis through an increase in tissue infiltrating Tregs. Here, we evaluated the effect of the short-chain fatty acid propionate on the chronic inflammatory state and T-cell composition in ESRD patients. Analyzing ESRD patients and healthy blood donors before, during, and 60 days after the propionate supplementation by multiparametric flow cytometry we observed a gradual and significant expansion in the frequencies of \(CD25^{high}CD127{−}\) Tregs in both groups. Phenotypic characterization suggests that polarization of naïve T cells towards Tregs is responsible for the observed expansion. In line with this, we observed a significant reduction of inflammatory marker CRP under propionate supplementation. Of interest, the observed anti-inflammatory surroundings did not affect the protective pathogen-specific immunity as demonstrated by the stable frequencies of effector/memory T cells specific for tetanus/diphtheria recall antigens. Collectively, our data suggest that dietary supplements with propionate have a beneficial effect on the elevated systemic inflammation of ESRD patients. The effect can be achieved through an expansion of circulating Tregs without affecting the protective pathogen-reactive immunity.
MetadatenAuthor: | Fabian MeyerGND, Felix Sebastian SeibertORCiDGND, Mikalai NienenGND, Marius WelzelGND, Daniela BeisserGND, Frederic BauerGND, Benjamin Johannes RohnGND, Timm WesthoffORCiDGND, Ulrik Stervbo-KristensenORCiDGND, Nina BabelORCiDGND |
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URN: | urn:nbn:de:hbz:294-89300 |
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DOI: | https://doi.org/10.1007/s40620-019-00694-z |
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Parent Title (English): | Journal of nephrology |
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Publisher: | Springer |
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Place of publication: | Milano |
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Document Type: | Article |
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Language: | English |
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Date of Publication (online): | 2022/05/12 |
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Date of first Publication: | 2020/03/06 |
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Publishing Institution: | Ruhr-Universität Bochum, Universitätsbibliothek |
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Tag: | End-stage renal disease; Propionate; Regulatory T-cells; Short-chain fatty acids |
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Volume: | 33 |
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First Page: | 817 |
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Last Page: | 827 |
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Note: | Dieser Beitrag ist auf Grund des DEAL-Springer-Vertrages frei zugänglich. |
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Institutes/Facilities: | Marienhospital Herne, Medizinische Klinik I |
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Dewey Decimal Classification: | Technik, Medizin, angewandte Wissenschaften / Medizin, Gesundheit |
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open_access (DINI-Set): | open_access |
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Licence (English): | Creative Commons - CC BY 4.0 - Attribution 4.0 International |
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