Corneal inflammatory cell infiltration predicts disease activity in chronic inflammatory demyelinating polyneuropathy
- The assessment of disease activity is fundamental in the management of chronic inflammatory demyelinating polyneuropathy (CIDP). Previous studies with small patient numbers found an increase of corneal immune cell infiltrates as a potential marker of inflammation in patients with CIDP. However, its clinical relevance remained unclear. The present study aimed to determine whether the amount of corneal inflammatory cells (CIC) measured by corneal confocal microscopy (CCM) detects disease activity in CIDP. CIC were measured in 142 CCM-investigations of 97 CIDP-patients. Data on clinical disease activity, disability (INCAT-ODSS) and need for therapy escalation at the timepoint of CCM, 3 and 6 months later were analyzed depending CIC-count. Pathological spontaneous activity during electromyography was examined as another possible biomarker for disease activity in comparison to CIC-count. An increased CIC-count at baseline was found in patients with clinical disease activity and disability progression in the following 3–6 months. An increase to more than 25 CIC/mm\(^{2}\) had a sensitivity of 0.73 and a specificity of 0.71 to detect clinical disease activity and a sensitivity of 0.77 and a specificity of 0.64 to detect disability progression (increasing INCAT-ODSS) in the following 6 months. An increase to more than 50 CIC/mm\(^{2}\) had a sensitivity of about 0.51 and a specificity of 0.91 to detect clinical disease activity and a sensitivity of 0.53 and a specificity of 0.80 to detect disability progression. CIC count is a non-invasive biomarker for the detection of disease activity in the following 6 months in CIDP.
Author: | Jeremias MotteORCiDGND, Thomas GrüterORCiDGND, Anna Lena FisseORCiDGND, Yesim BulutGND, Zornitsa StykovaGND, Tineke GreinerGND, Elena K. KrumovaORCiDGND, Min-Suk YoonGND, Ralf GoldORCiDGND, Martin TegenthoffGND, Dietrich SturmGND, Kalliopi PitarokoiliORCiDGND |
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URN: | urn:nbn:de:hbz:294-91538 |
DOI: | https://doi.org/10.1038/s41598-021-94605-7 |
Parent Title (English): | Scientific reports |
Publisher: | Springer Nature |
Place of publication: | Berlin |
Document Type: | Article |
Language: | English |
Date of Publication (online): | 2022/07/26 |
Date of first Publication: | 2021/07/26 |
Publishing Institution: | Ruhr-Universität Bochum, Universitätsbibliothek |
Tag: | Open Access Fonds Neurology; Peripheral neuropathies; Predictive markers; Prognostic markers |
Volume: | 11 |
Issue: | Artikel 15150 |
First Page: | 15150-1 |
Last Page: | 15150-8 |
Note: | Article Processing Charge funded by the Open Access Publication Fund of Ruhr-Universität Bochum. |
Institutes/Facilities: | St. Josef-Hospital Bochum, Neurologische Klinik |
Dewey Decimal Classification: | Technik, Medizin, angewandte Wissenschaften / Medizin, Gesundheit |
open_access (DINI-Set): | open_access |
Licence (English): | Creative Commons - CC BY 4.0 - Attribution 4.0 International |