Needle-free and needle-based growth hormone therapy in children
- \(\bf Background:\) Treatment with growth hormone (GH) is standard clinical practice in children with GH deficiency (GHD) or Turner syndrome (TS). Hitherto, no long-term data on auxological outcome and safety of Zomacton® have been published. Data comparing needle-free administration (NF) and needle injection (NI) of GH are very sparse. \(\bf Aims:\) To analyse longitudinal auxological outcome and safety data of GH treatment-naïve patients diagnosed with GHD or TS and to compare NF and NI in a real-life setting. \(\bf Methods:\) Pooled auxological data and safety information from three consecutive prospective observational Zomacton® studies covering 22 years of treatment were analysed and NF was compared to NI. \(\bf Results:\) The safety cohort comprised 1,595 patients who received at least one GH dose. The auxological outcome cohort comprised 856 treatment-naïve patients with follow-up data \(\geq\) 12 months. Height-SDS and height velocity improved significantly during the first 3 years of treatment. Documented choice of device was available for 658 patients (NF 69.1%, NI 30.9%). NF administration was non-inferior to NI. No previously unknown safety signals occurred. \(\bf Conclusion:\) Real-life data show that treatment with Zomacton® improves auxological outcome parameters without new safety concerns. NF administration of GH represents a useful alternative to NI in children with growth disorders.
Author: | Tilman R. RohrerGND, Sabine Ceplis-KastnerGND, Norbert JorchGND, Hermann L. MüllerGND, Roland PfäffleGND, Thomas ReinehrGND, Annette Richter-UnruhGND, Claudia WeißenbacherGND, Paul-Martin HolterhusGND |
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URN: | urn:nbn:de:hbz:294-93242 |
DOI: | https://doi.org/10.1159/000496614 |
Parent Title (English): | Hormone research in paediatrics |
Subtitle (English): | a pooled analysis of three long-term observational studies |
Publisher: | Karger |
Place of publication: | Basel |
Document Type: | Article |
Language: | English |
Date of Publication (online): | 2022/10/11 |
Date of first Publication: | 2019/03/05 |
Publishing Institution: | Ruhr-Universität Bochum, Universitätsbibliothek |
Tag: | Auxological outcome; Growth hormone deficiency; Jet delivery; Somatropin; Turner syndrome |
Volume: | 90 |
Issue: | 6 |
First Page: | 393 |
Last Page: | 406 |
Note: | Dieser Beitrag ist aufgrund einer nationalen Lizenz frei zugänglich. |
Institutes/Facilities: | Katholisches Klinikum Bochum, Kinderendokrinologie und Diabetologie |
Dewey Decimal Classification: | Technik, Medizin, angewandte Wissenschaften / Medizin, Gesundheit |
open_access (DINI-Set): | open_access |
Licence (German): | Nationale Lizenz |