Antibiotic prophylaxis for prevention of wound infections after soft tissue sarcoma resection
- Background and Objectives The use of antibiotic prophylaxis for soft tissue sarcoma resection varies widely while little evidence on this topic exists. The aim of this study was to determine the impact of antibiotic prophylaxis on the occurrence of wound infections. Methods A single institutional retrospective cohort study was performed on patients who underwent truncal or extremity soft tissue sarcoma resection. The use of antibiotic prophylaxis was assessed and univariate and multivariate analysis of predictors of wound infections was performed. Results Nine hundred and fifty-eight patients could be included. Thirty-two percent of patients had no antibiotic prophylaxis, 44% of patients received single-shot prophylaxis, and 24% of patients received single-shot plus continued antibiotic treatment. Wound infections occurred in 140 patients (15%). Independent risk factors for wound infections upon multivariate analysis were obesity, high American Society of Anesthesiologists (ASA) status, high tumor size and grade, operation time over 120 minutes, and other complications. Antibiotic prophylaxis could not be identified as a protective factor in univariate or multivariate analysis. Conclusions A favorable effect of antibiotic prophylaxis on the occurrence of wound infections could not be observed. Although more studies on this subject are needed, our data do not support the general use of antibiotic prophylaxis for soft tissue sarcoma resection.
Author: | Mehran DadrasORCiDGND, Pascal KoeppGND, Johannes Maximilian WagnerORCiDGND, Christoph WallnerGND, Alexander Klaus SogorskiORCiDGND, Marcus LehnhardtGND, Kamran HaratiGND, Björn BehrORCiDGND |
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URN: | urn:nbn:de:hbz:294-100050 |
DOI: | https://doi.org/10.1002/jso.26188 |
Parent Title (English): | Journal of surgical oncology |
Subtitle (English): | A retrospective cohort study |
Publisher: | Wiley |
Place of publication: | Hoboken, New Jersey |
Document Type: | Article |
Language: | English |
Date of Publication (online): | 2023/06/30 |
Date of first Publication: | 2020/08/26 |
Publishing Institution: | Ruhr-Universität Bochum, Universitätsbibliothek |
Tag: | antibiotic prophylaxis; sarcoma; soft tissue sarcoma; wound infection |
Volume: | 122 |
Issue: | 8 |
First Page: | 1685 |
Last Page: | 1692 |
Note: | Dieser Beitrag ist auf Grund des DEAL-Wiley-Vertrages frei zugänglich. |
Institutes/Facilities: | Berufsgenossenschaftliches Universitätsklinikum Bergmannsheil, Klinik für Plastische Chirurgie und Schwerbrandverletzte |
Dewey Decimal Classification: | Technik, Medizin, angewandte Wissenschaften / Medizin, Gesundheit |
open_access (DINI-Set): | open_access |
faculties: | Medizinische Fakultät |
Licence (English): | Creative Commons - CC BY 4.0 - Attribution 4.0 International |