Jacqueline Niewolik, Marie Mikuteit, Anne Cossmann, Kai Vahldiek, Ralf Gutzmer, Frank Müller, Dominik Schröder, Stephanie Heinemann, Georg M.N. Behrens, Alexandra Dopfer-Jablonka, Sandra Steffens, Imke Grimmelmann
- \(\bf Background:\) Immunogenicity of SARS-CoV-2 vaccines is modestly impaired in cancer patients due to a generally weakened immune system. Immune checkpoint inhibitors (ICI) are expected to enhance immune response. This has already been described to be the case in influenza vaccines, and first data about COVID-19 vaccines show a trend in this direction.
\(\bf Aim:\) We aimed to investigate the immune response of patients with melanoma under ICI therapy after COVID-19 vaccination.
\(\textbf {Patients and Methods:}\) In the Skin Cancer Center Hanover (Germany), we recruited 60 patients with advanced melanoma who either received ICI therapy during or before the vaccination period. Serological blood analysis was performed using quantitative ELISA for Anti-SARS-CoV-2 spike protein 1 IgG antibodies.
\(\bf Results:\) We did not observe an enhanced humoral immune response in patients under active or past ICI therapy after COVID-19 vaccination. Nevertheless, there is a tendency of higher antibody levels when ICI therapy was received within the last 6 months before vaccination. Subgroup analysis revealed that patients in our study population under ongoing targeted therapy during vaccination period had significantly higher median antibody levels than patients without any active antitumor treatment.
\(\bf Conclusion:\) Melanoma patients under ICI therapy show comparable antibody response after SARS-CoV-2 vaccination to healthy health care professionals. This finding is independent of the timing of ICI therapy.
MetadatenAuthor: | Jacqueline NiewolikGND, Marie MikuteitGND, Anne CossmannGND, Kai VahldiekORCiDGND, Ralf GutzmerGND, Frank MüllerORCiDGND, Dominik SchröderGND, Stephanie HeinemannORCiDGND, Georg M.N. BehrensORCiDGND, Alexandra Dopfer-JablonkaORCiDGND, Sandra SteffensGND, Imke GrimmelmannGND |
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URN: | urn:nbn:de:hbz:294-101439 |
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DOI: | https://doi.org/10.1159/000524894 |
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Parent Title (English): | Oncology |
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Publisher: | Karger |
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Place of publication: | Basel |
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Document Type: | Article |
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Language: | English |
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Date of Publication (online): | 2023/09/01 |
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Date of first Publication: | 2022/05/24 |
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Publishing Institution: | Ruhr-Universität Bochum, Universitätsbibliothek |
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Tag: | Advanced melanoma; COVID-19 vaccination; Immune checkpoint inhibitors; Immunogenicity; SARS-CoV-2 |
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Volume: | 100 |
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Issue: | 7 |
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First Page: | 392 |
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Last Page: | 398 |
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Note: | Dieser Beitrag ist aufgrund einer konsortialen Lizenz frei zugänglich. |
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Institutes/Facilities: | Johannes Wesling Klinikum Minden, Klinik für Dermatologie, Venerologie, Allergologie und Phlebologie |
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Dewey Decimal Classification: | Technik, Medizin, angewandte Wissenschaften / Medizin, Gesundheit |
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open_access (DINI-Set): | open_access |
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Licence (German): | Konsortiale Lizenz |
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