Parallel modulation of intracortical excitability of somatosensory and visual cortex by the gonadal hormones estradiol and progesterone
- The levels of the gonadal hormones estradiol and progesterone vary throughout the menstrual cycle thereby affecting cognition, emotion, mood, and social behaviour. However, how these hormones modulate the balance of neural excitation and inhibition, which crucially regulate processing and plasticity, is not fully understood. We here used paired-pulse stimulation to investigate in healthy humans the action of low and high estradiol and progesterone on intracortical inhibition in somatosensory (SI) and visual cortex (V1). We found that paired-pulse suppression in both SI and VI depended on estradiol. During high estradiol levels, paired-pulse suppression was significantly reduced. No comparable effects were found for progesterone, presumably due to a confounding effect of estradiol. Also, no hormone level-depending effects were observed for single-pulse evoked SEPs (somatosensory evoked potentials) and VEPs (visual evoked potentials) indicating a specific hormonal action on intracortical processing. The results demonstrate that estradiol globally modulates the balance of excitation and inhibition of SI and VI cortex.
Author: | Nasim SchlömerGND, Melanie LenzGND, Martin TegenthoffGND, Hubert R. DinseORCiDGND, Oliver HöffkenGND |
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URN: | urn:nbn:de:hbz:294-96580 |
DOI: | https://doi.org/10.1038/s41598-020-79389-6 |
Parent Title (English): | Scientific reports |
Publisher: | Macmillan Publishers Limited, part of Springer Nature |
Place of publication: | London |
Document Type: | Article |
Language: | English |
Date of Publication (online): | 2023/02/15 |
Date of first Publication: | 2020/12/17 |
Publishing Institution: | Ruhr-Universität Bochum, Universitätsbibliothek |
Volume: | 10 |
Issue: | Article 22237 |
First Page: | 22237-1 |
Last Page: | 22237-13 |
Note: | Dieser Beitrag ist auf Grund des DEAL-Springer-Vertrages frei zugänglich. |
Institutes/Facilities: | Institut für Neuroinformatik |
Berufsgenossenschaftliches Universitätsklinikum Bergmannsheil, Neurologische Universitätsklinik und Poliklinik | |
Dewey Decimal Classification: | Technik, Medizin, angewandte Wissenschaften / Medizin, Gesundheit |
open_access (DINI-Set): | open_access |
Licence (English): | Creative Commons - CC BY 4.0 - Attribution 4.0 International |