Swetlana Ladigan-Badura, Deepak Vangala, Christoph Engel, Karolin Bucksch, Robert Hueneburg, Claudia Perne, Jacob Nattermann, Verena Steinke-Lange, Nils Rahner, Hans K. Schackert, Jürgen Weitz, Matthias Kloor, Judith Kuhlkamp, Huu Phuc Nguyen, Gabriela Moeslein, Christian Strassburg, Monika Morak, Elke Holinski-Feder, Reinhard Buettner, Stefan Aretz, Markus Loeffler, Wolff-Helmut Schmiegel, Christian Pox, Karsten Schulmann
- In our study, we evaluated the effectiveness of upper gastrointestinal (GI) endoscopy as an instrument for early gastric cancer (GC) detection in Lynch syndrome (LS) patients by analyzing data from the registry of the \(\textit {German Consortium for Familial Intestinal Cancer}\). In a prospective, multicenter cohort study, 1128 out of 2009 registered individuals with confirmed LS underwent 5176 upper GI endoscopies. Compliance was good since 77.6% of upper GI endoscopies were completed within the recommended interval of 1 to 3 years. Forty-nine GC events were observed in 47 patients. \(\it MLH1\) (n = 21) and \(\it MSH2\) (n = 24) mutations were the most prevalent. GCs in patients undergoing regular surveillance were diagnosed significantly more often in an early-stage disease (UICC I) than GCs detected through symptoms (83% vs 25%; \(\it P\) = .0231). Thirty-two (68%) patients had a negative family history of GC. The median age at diagnosis was 51 years (range 28-66). Of all GC patients, 13 were diagnosed at an age younger than 45. Our study supports the recommendation of regular upper GI endoscopy surveillance for LS patients beginning no later than at the age of 30.
MetadatenAuthor: | Swetlana Ladigan-BaduraORCiDGND, Deepak VangalaORCiDGND, Christoph EngelORCiDGND, Karolin BuckschORCiDGND, Robert HueneburgORCiDGND, Claudia PerneORCiDGND, Jacob NattermannORCiDGND, Verena Steinke-LangeORCiDGND, Nils RahnerGND, Hans K. SchackertGND, Jürgen WeitzGND, Matthias KloorGND, Judith KuhlkampGND, Huu Phuc NguyenORCiDGND, Gabriela MoesleinORCiDGND, Christian StrassburgORCiDGND, Monika MorakORCiDGND, Elke Holinski-FederORCiDGND, Reinhard BuettnerORCiDGND, Stefan AretzORCiDGND, Markus LoefflerORCiDGND, Wolff-Helmut SchmiegelGND, Christian PoxGND, Karsten SchulmannGND |
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URN: | urn:nbn:de:hbz:294-99340 |
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DOI: | https://doi.org/10.1002/ijc.33294 |
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Parent Title (English): | International journal of cancer |
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Publisher: | Wiley |
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Place of publication: | Hoboken, New Jersey |
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Document Type: | Article |
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Language: | English |
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Date of Publication (online): | 2023/06/01 |
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Date of first Publication: | 2020/09/15 |
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Publishing Institution: | Ruhr-Universität Bochum, Universitätsbibliothek |
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Tag: | HNPCC; Lynch syndrome; gastric cancer; screening; surveillance |
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Volume: | 148 |
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Issue: | 1 |
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First Page: | 106 |
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Last Page: | 114 |
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Note: | Dieser Beitrag ist auf Grund des DEAL-Wiley-Vertrages frei zugänglich. |
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Institutes/Facilities: | Knappschaftskrankenhaus Bochum, Medizinische Klinik, Hämatologie / Onkologie |
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Dewey Decimal Classification: | Technik, Medizin, angewandte Wissenschaften / Medizin, Gesundheit |
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open_access (DINI-Set): | open_access |
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faculties: | Medizinische Fakultät |
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Licence (English): | Creative Commons - CC BY-NC-ND 4.0 - Attribution-NonCommercial-NoDerivatives 4.0 International |
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