- The experience of adversity in childhood has been associated with poor health outcomes in adulthood. In search of the biological mechanisms underlying these effects, research so far focused on alterations of DNA methylation or shifts in transcriptomic profiles. The level of protein, however, has been largely neglected. We utilized mass spectrometry to investigate the proteome of \(CD14^{+}\) monocytes in healthy adults reporting childhood adversity and a control group before and after psychosocial stress exposure. Particular proteins involved in (i) immune processes, such as neutrophil-related proteins, (ii) protein metabolism, or (iii) proteins related to mitochondrial biology, such as those involved in energy production processes, were upregulated in participants reporting exposure to adversity in childhood. This functional triad was further corroborated by protein interaction- and co-expression analyses, was independent of stress exposure, i.e. observed at both pre- and post-stress time points, and became evident especially in females. In line with the mitochondrial allostatic load model, our findings provide evidence for the long-term effects of childhood adversity on mitochondrial biology.
MetadatenAuthor: | Johannes ZangORCiDGND, Caroline MayORCiDGND, Birte HellwigORCiDGND, Dirk MoserORCiDGND, Jan G. HengstlerORCiDGND, Steve ColeGND, Markus HeinrichsGND, Jörg RahnenführerGND, Katrin Marcus-AlicORCiDGND, Robert KumstaORCiDGND |
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URN: | urn:nbn:de:hbz:294-106338 |
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DOI: | https://doi.org/10.1038/s41398-023-02320-w |
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Parent Title (English): | Translational psychiatry |
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Publisher: | Springer Nature Publishing Group |
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Place of publication: | London |
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Document Type: | Article |
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Language: | English |
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Date of Publication (online): | 2024/01/17 |
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Date of first Publication: | 2023/02/01 |
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Publishing Institution: | Ruhr-Universität Bochum, Universitätsbibliothek |
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Tag: | Open Access Fonds |
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Volume: | 13 |
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Issue: | Article 31 |
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First Page: | 31-1 |
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Last Page: | 31-12 |
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Note: | Article Processing Charge funded by the Deutsche Forschungsgemeinschaft (DFG) and the Open Access Publication Fund of Ruhr-Universität Bochum. |
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Institutes/Facilities: | Fakultät für Psychologie, Lehrstuhl für Genetische Psychologie |
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| Zentrum für Protein-Diagnostik (PRODI) |
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Dewey Decimal Classification: | Philosophie und Psychologie / Psychologie |
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open_access (DINI-Set): | open_access |
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faculties: | Fakultät für Psychologie |
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Licence (English): | Creative Commons - CC BY 4.0 - Attribution 4.0 International |
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