Monooxygenases
- Biocatalysis, the use of natural catalysts (enzymes) for the selective and environmentally friendly conversion of synthetic chemicals for pharmaceutical, agrochemical or fine chemical applications has received interest from academia and industry during recent years. A class of chemical reactions which is of particular interest but of high complexity is the oxidation of organic molecules using air as the oxidant. New enzymes were developed as catalysts for oxidation reactions by identifying novel enzymes and by improving existing ones. The enzyme families under study were the Cytochrome P450s and Baeyer-Villiger Monooxygenases. Efficient procedures were developed which allow for the synthetic application of these enzymes with high stereoselectivities and high catalyst lifetimes. A new method was developed which enables the use of sunlight as the energy source for these reactions instead of the usual chemical energy, which helps in paving the way towards clean organic synthesis.
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| Author: | Frank SchulzORCiDGND |
|---|---|
| URN: | urn:nbn:de:hbz:294-22582 |
| Subtitle (English): | experiments to turn a class of enzymes into a toolbox for biocatalysis |
| Referee: | Manfred T. ReetzGND, Martin FeigelGND |
| Document Type: | Doctoral Thesis |
| Language: | English |
| Date of Publication (online): | 2008/07/19 |
| Date of first Publication: | 2008/07/19 |
| Publishing Institution: | Ruhr-Universität Bochum, Universitätsbibliothek |
| Granting Institution: | Ruhr-Universität Bochum, Fakultät für Chemie und Biochemie |
| Date of final exam: | 2007/04/27 |
| Creating Corporation: | Fakultät für Chemie und Biochemie |
| GND-Keyword: | Biokatalyse; Organische Synthese; Biochemie; Enzymkatalyse; Asymmetrische Synthese |
| Dewey Decimal Classification: | Naturwissenschaften und Mathematik / Chemie, Kristallographie, Mineralogie |
| Licence (German): |  Keine Creative Commons Lizenz - es gelten der Veröffentlichungsvertrag und das deutsche Urheberrecht |
