Genetic variation in dopamine availability modulates the self-reported level of action control in a sex-dependent manner

  • Although procrastination is a widespread phenomenon with significant influence on our personal and professional life, its genetic foundation is somewhat unknown. An important factor that influences our ability to tackle specific goals directly instead of putting them off is our ability to initiate cognitive, motivational and emotional control mechanisms, so-called metacontrol. These metacontrol mechanisms have been frequently related to dopaminergic signaling. To gain deeper insight into the genetic components of procrastination, we examined whether genetically induced differences in the dopaminergic system are associated with interindividual differences in trait-like procrastination, measured as decision-related action control (AOD). Analyzing the data of 278 healthy adults, we found a sex-dependent effect of TH genotype on AOD. Interestingly, only in women, T-allele carriers showed lower AOD values and were therefore more likely to procrastinate. Additionally, we investigated whether differences in the morphology and functional connectivity of the amygdala that were previously associated with AOD happen to be related to differences in the TH genotype and thus to differences in the dopaminergic system. However, there was no significant amygdala volume or connectivity difference between the TH genotype groups. Therefore, this study is the first to suggest that genetic, anatomical and functional differences affect trait-like procrastination independently.

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Author:Caroline SchlüterORCiDGND, Larissa ArningORCiDGND, Christoph FraenzGND, Patrick FriedrichGND, Marlies PinnowGND, Onur GüntürkünORCiDGND, Christian BesteGND, Sebastian OcklenburgORCiDGND, Erhan GençGND
URN:urn:nbn:de:hbz:294-73046
DOI:https://doi.org/10.1093/scan/nsz049
Parent Title (English):Social cognitive and affective neuroscience
Publisher:Oxford University Press
Place of publication:Oxford
Document Type:Article
Language:English
Date of Publication (online):2020/07/09
Date of first Publication:2019/07/03
Publishing Institution:Ruhr-Universität Bochum, Universitätsbibliothek
Tag:Open Access Fonds
TH genotype; action control; dopamine; sex differences; structural and functional MRI
Volume:14
Issue:7
First Page:759
Last Page:768
Note:
Article Processing Charge funded by the Deutsche Forschungsgemeinschaft (DFG) and the Open Access Publication Fund of Ruhr-Universität Bochum.
Institutes/Facilities:Fakultät für Psychologie, Arbeitseinheit Biopsychologie
Dewey Decimal Classification:Philosophie und Psychologie / Psychologie
open_access (DINI-Set):open_access
faculties:Fakultät für Psychologie
Licence (English):License LogoCreative Commons - CC BY-NC 4.0 - Attribution-NonCommercial 4.0 International