Regulation and function of the phytochrome system in \(\textit {Pseudomonas aeruginosa}\)
- Phytochromes are red/far-red light photoreceptors found in plants and have recently also been discovered in bacteria. Biochemical analysis established that the genes \(\it {bphO}\) and \(\it {bphP}\) display the two necessary phytochrome components in the opportunistic pathogen \(\textit {Pseudomonas aeruginosa: bphO}\) encoding a heme oxygenase that produces the chromophore biliverdin IX\(\alpha\) and \(\it {bphP}\) encoding the apo-phytochrome. Transcriptional analyses established that both genes form a bicistronic operon. Expression of the \(\it {bphOP}\) operon was shown to be induced in the stationary phase dependent on the alternative sigma factor, RpoS. Interestingly, the loss of BphO but not BphP led to pronounced phenotypes in the stationary phase suggesting an additional role of BphO besides providing the chromophore to BphP. Transcriptome and proteom studies on the other hand revealed that BphP is involved in the regulation of various gene clusters and pointed to a link of BphP function with the \(\textit {P. aeruginosa}\) quorum sensing system.
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| Author: | Katalin BarkovitsORCiDGND |
|---|---|
| URN: | urn:nbn:de:hbz:294-28047 |
| Title Additional (German): | Regulation und Funktion des Phytochromsystems in \(\textit {Pseudomonas aeruginosa}\) |
| Referee: | Nicole FrankenbergGND, Danja SchünemannGND |
| Document Type: | Doctoral Thesis |
| Language: | English |
| Date of Publication (online): | 2010/04/14 |
| Date of first Publication: | 2010/04/14 |
| Publishing Institution: | Ruhr-Universität Bochum, Universitätsbibliothek |
| Granting Institution: | Ruhr-Universität Bochum, Fakultät für Biologie und Biotechnologie |
| Date of final exam: | 2009/10/06 |
| Creating Corporation: | Fakultät für Biologie und Biotechnologie |
| Tag: | Pseudomonas aeruginosa |
| GND-Keyword: | Phytochrom; Protein-Histidin-Kinasen; Hämoxygenase; Stationäre Phase; Biliverdin |
| Institutes/Facilities: | Lehrstuhl für Biologie der Mikroorganismen, Arbeitsgruppe Physiologie der Mikroorganismen |
| Dewey Decimal Classification: | Naturwissenschaften und Mathematik / Biowissenschaften, Biologie, Biochemie |
| faculties: | Fakultät für Biologie und Biotechnologie |
| Licence (German): |  Keine Creative Commons Lizenz - es gelten der Veröffentlichungsvertrag und das deutsche Urheberrecht |
