Changes in pre- and postsynaptic function during the phase of enhanced long-term synaptic plasticity at the border of focal lesions in rat visual cortex
Änderungen der prä- und postsynaptischen Funktion in der Phase verstärkter synaptischer Plastizität im Randbereich von fokalen Läsionen im visuellen Kortex der Ratte
- Focal lesions in the visual cortex have been shown to induce enlarged receptive field sizes and an enhanced long-term potentiation (LTP). However, the synaptic mechanism of the lesion-induced facilitation of LTP is not fully understood. Therefore, the present thesis studied possible changes in pre- and postsynaptic function of neurons located at the border of lesion in rat visual cortex. This study showed an increased presynaptic glutamate release probability in lesion-treated visual cortex. The enhanced presynaptic glutamate release is mediated by activation of the presynaptic NMDARs and BDNF-TrkB receptor pathway. The lesion also affects the functional properties of postsynaptically located NMDARs containing the NR2B subunits. In addition, neurons at the border of the injury showed a decreased GABAergic inhibition. The findings of the present study indicate that a focal cortical lesion in visual cortex changes both, the pre- and postsynaptic function of neighbouring neurons.
Author: | Li Yan |
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URN: | urn:nbn:de:hbz:294-22067 |
Referee: | Thomas MittmannORCiDGND, Hanns HattGND |
Document Type: | Doctoral Thesis |
Language: | English |
Date of Publication (online): | 2008/04/18 |
Date of first Publication: | 2008/04/18 |
Publishing Institution: | Ruhr-Universität Bochum, Universitätsbibliothek |
Granting Institution: | Ruhr-Universität Bochum, International Graduate School of Neuroscience |
Date of final exam: | 2008/01/14 |
Creating Corporation: | International Graduate School of Neuroscience |
GND-Keyword: | Läsion; Sehrinde; Syaptische Transmission; Langzeitpotenzierung; NMDA-Rezeptor |
Institutes/Facilities: | Medizinische Fakultät, Abteilung für Neurophysiologie |
Dewey Decimal Classification: | Technik, Medizin, angewandte Wissenschaften / Medizin, Gesundheit |
Licence (German): | Keine Creative Commons Lizenz - es gelten der Veröffentlichungsvertrag und das deutsche Urheberrecht |