Changes in pre- and postsynaptic function during the phase of enhanced long-term synaptic plasticity at the border of focal lesions in rat visual cortex

Änderungen der prä- und postsynaptischen Funktion in der Phase verstärkter synaptischer Plastizität im Randbereich von fokalen Läsionen im visuellen Kortex der Ratte

  • Focal lesions in the visual cortex have been shown to induce enlarged receptive field sizes and an enhanced long-term potentiation (LTP). However, the synaptic mechanism of the lesion-induced facilitation of LTP is not fully understood. Therefore, the present thesis studied possible changes in pre- and postsynaptic function of neurons located at the border of lesion in rat visual cortex. This study showed an increased presynaptic glutamate release probability in lesion-treated visual cortex. The enhanced presynaptic glutamate release is mediated by activation of the presynaptic NMDARs and BDNF-TrkB receptor pathway. The lesion also affects the functional properties of postsynaptically located NMDARs containing the NR2B subunits. In addition, neurons at the border of the injury showed a decreased GABAergic inhibition. The findings of the present study indicate that a focal cortical lesion in visual cortex changes both, the pre- and postsynaptic function of neighbouring neurons.

Download full text files

Export metadata

Additional Services

Share in Twitter Search Google Scholar
Metadaten
Author:Li Yan
URN:urn:nbn:de:hbz:294-22067
Referee:Thomas MittmannORCiDGND, Hanns HattGND
Document Type:Doctoral Thesis
Language:English
Date of Publication (online):2008/04/18
Date of first Publication:2008/04/18
Publishing Institution:Ruhr-Universität Bochum, Universitätsbibliothek
Granting Institution:Ruhr-Universität Bochum, International Graduate School of Neuroscience
Date of final exam:2008/01/14
Creating Corporation:International Graduate School of Neuroscience
GND-Keyword:Läsion; Sehrinde; Syaptische Transmission; Langzeitpotenzierung; NMDA-Rezeptor
Institutes/Facilities:Medizinische Fakultät, Abteilung für Neurophysiologie
Dewey Decimal Classification:Technik, Medizin, angewandte Wissenschaften / Medizin, Gesundheit
Licence (German):License LogoKeine Creative Commons Lizenz - es gelten der Veröffentlichungsvertrag und das deutsche Urheberrecht