Down regulation of \(\it {ras}\) protein by Metal Macrocycles
- The small guanine nucleotide binding protein \(\it {Ras}\) is involved in cellular signal transduction and cell proliferation. Conformation states of p21\(_{ras}\) are associated with interaction of effectors regulating the signal transduction and cell proliferation. From NMR studies it is revealed that state 2 is an active form of GTP bound \(\it {Ras}\) with high affinity to Raf-Kinase, while state 1 is shown to be a conformation similar to GDP bound state. Stabilization of this latter state has an importance in development of antitumor strategies by regulating the interaction of effectors with active and inactive states of nucleotide bound \(\it {Ras}\). Here ubiquitous Ras*GTP properties and its interaction with effectors were investigated in order to down regulate the signal transduction from the following strategies A) Switching mechanism, B) Acceleration of GTP hydrolysis by metal macrocycles C) Emulating GTPase Activating Protein mimics D) Photo Dynamic Therapeutic Applications on Nucleotide dissociation.
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| Author: | Ravi Shankar BojjaGND |
|---|---|
| URN: | urn:nbn:de:hbz:294-22213 |
| Referee: | Klaus GerwertORCiDGND, Hermann LübbertORCiDGND, Gerhard LinkORCiDGND |
| Document Type: | Doctoral Thesis |
| Language: | English |
| Date of Publication (online): | 2008/05/15 |
| Date of first Publication: | 2008/05/15 |
| Publishing Institution: | Ruhr-Universität Bochum, Universitätsbibliothek |
| Granting Institution: | Ruhr-Universität Bochum, Fakultät für Biologie und Biotechnologie |
| Date of final exam: | 2008/04/17 |
| Creating Corporation: | Fakultät für Biologie und Biotechnologie |
| GND-Keyword: | Ras-Proteine / Regulation; Signaltransduktion; Guanosintriphosphat; Hydrolyse; Nukleotide / Dissoziation |
| Dewey Decimal Classification: | Naturwissenschaften und Mathematik / Biowissenschaften, Biologie, Biochemie |
| faculties: | Fakultät für Biologie und Biotechnologie |
| Licence (German): |  Keine Creative Commons Lizenz - es gelten der Veröffentlichungsvertrag und das deutsche Urheberrecht |
