Apoptose der Koronarendothelzellen unter Ischämie-Bedingungen
- The goal of the dissertation was to analyse the mechanisms of the coronary endothelial cells (EC) apoptosis induced by simulated ischemia (glucose-free anoxia and acidosis). The main findings are the following: 1. Ischemic acidosis is an important trigger of apoptosis in coronary EC. This EC apoptosis is mainly (about 70%) mediated by an endoplasmic reticulum dependent pathway through the activation of caspase-12, whereas mitochondria play only a minor role. 2. Activity of the mitochondrial pathway is under control of bicarbonate-dependent ion transport. Inhibition of the bicarbonate transport leads to activation of this pathway: translocation of Bax to mitochondria, mitochondrial depolarisation and release of cytochrome C. 3. Short pre-treatment with acidosis (pH 6.4) protects endothelial cells against ischemic apoptosis by inhibition of endoplasmic reticulum- and mitochondria-dependent pathways and was associated with overexpression of anti-apoptotic protein Bcl-xL.
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| Author: | Sanjeev KumarGND |
|---|---|
| URN: | urn:nbn:de:hbz:294-19957 |
| Subtitle (Multiple languages): | experimentelle Analyse der Signalwege und Protektionsstrategie |
| Subtitle (English): | experimental analysis of signalling pathways and protection strategy |
| Title Additional (English): | Apoptosis of the coronary endothelial cells under ischemic conditions |
| Referee: | Hans-Peter ReuschGND, Hermann LübbertORCiDGND |
| Document Type: | Doctoral Thesis |
| Language: | Multiple languages |
| Date of Publication (online): | 2007/08/14 |
| Date of first Publication: | 2007/08/14 |
| Publishing Institution: | Ruhr-Universität Bochum, Universitätsbibliothek |
| Granting Institution: | Ruhr-Universität Bochum, Fakultät für Biologie und Biotechnologie |
| Date of final exam: | 2007/07/04 |
| Creating Corporation: | Fakultät für Biologie und Biotechnologie |
| GND-Keyword: | Herz / Endothelzelle; Ischämie; Apoptosis; Azidose; Cytochrom c |
| Institutes/Facilities: | Institut für Pharmakologie und Toxikologie, Abteilung für klinische Pharmakologie |
| Dewey Decimal Classification: | Naturwissenschaften und Mathematik / Biowissenschaften, Biologie, Biochemie |
| faculties: | Fakultät für Biologie und Biotechnologie |
| Licence (German): |  Keine Creative Commons Lizenz - es gelten der Veröffentlichungsvertrag und das deutsche Urheberrecht |
