Combination of MiR-103a-3p and mesothelin improves the biomarker performance of malignant mesothelioma diagnosis

  • \(\bf\textit{Background:}\) For the detection of malignant mesothelioma no single biomarker with reasonable sensitivity and specificity has been described so far. Mesothelin, the most prominent blood-based biomarker, is characterized by high specificity but low sensitivity. It might be reasonable to combine biomarkers of different molecular classes in order to improve the overall performance. The aim of this study was to assess the performance of the combination of mesothelin and miR-103a-3p as blood-based biomarker for mesothelioma. \(\bf\textit{Methods/Principal Findings:}\) Mesothelin concentration in plasma and miR-103a-3p levels in the cellular blood fraction were analyzed in 43 male mesothelioma patients and 52 male controls formerly exposed to asbestos. For the discrimination of epithelioid and biphasic mesothelioma from asbestos-exposed controls mesothelin and miR-103a-3p showed 74% and 89% sensitivity and 85% and 63% specificity, respectively. For the combination of mesothelin and miR-103a-3p a sensitivity of 95% and a specificity of 81% were calculated. \(\bf\textit{Conclusions/Significance:}\) The results of this study show that the combination of mesothelin and miR-103a-3p improves the diagnostic performance of individual blood-based biomarker to detect malignant mesothelioma. The obtained results indicate that the use of biomarkers of different molecular classes might be a reasonable approach to assemble a biomarker panel.

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Metadaten
Author:Daniel G. WeberORCiDGND, Swaantje CasjensORCiDGND, Georg JohnenORCiDGND, Oleksandr BrykGND, Irina RaikoGND, Beate PeschORCiDGND, Jens KollmeierGND, Torsten Thomas BauerGND, Thomas BrüningORCiDGND
URN:urn:nbn:de:hbz:294-57596
DOI:https://doi.org/10.1371/journal.pone.0114483
Parent Title (English):PLoS one
Document Type:Article
Language:English
Date of Publication (online):2018/06/26
Date of first Publication:2014/12/03
Publishing Institution:Ruhr-Universität Bochum, Universitätsbibliothek
Tag:Open Access Fonds
Volume:9
Issue:12
First Page:e114483-1
Last Page:e114483-15
Note:
Article Processing Charge funded by the Deutsche Forschungsgemeinschaft (DFG) and the Open Access Publication Fund of Ruhr-Universität Bochum.
Note:
PLoS ONE, Bd. 9.2014, H. 12, Artikelnummer e114483
Institutes/Facilities:Institut für Prävention und Arbeitsmedizin der Deutschen Gesetzlichen Unfallversicherung
Dewey Decimal Classification:Technik, Medizin, angewandte Wissenschaften / Medizin, Gesundheit
open_access (DINI-Set):open_access
faculties:Medizinische Fakultät
Licence (English):License LogoCreative Commons - CC BY 4.0 - Attribution 4.0 International