Trafficking of kainate receptors

  • Ionotropic glutamate receptors (iGluRs) mediate the vast majority of excitatory neurotransmission in the central nervous system of vertebrates. In the protein family of iGluRs, kainate receptors (KARs) comprise the probably least well understood receptor class. Although KARs act as key players in the regulation of synaptic network activity, many properties and functions of these proteins remain elusive until now. Especially the precise pre-, extra-, and postsynaptic localization of KARs plays a critical role for neuronal function, as an unbalanced localization of KARs would ultimately lead to dysregulated neuronal excitability. Recently, important advances in the understanding of the regulation of surface expression, function, and agonist-dependent endocytosis of KARs have been achieved. Post-translational modifications like PKC-mediated phosphorylation and SUMOylation have been reported to critically influence surface expression and endocytosis, while newly discovered auxiliary proteins were shown to shape the functional properties of KARs.

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Metadaten
Author:Steffen PahlGND, Daniel TapkenORCiDGND, Simon HaeringGND, Michael HollmannORCiDGND
URN:urn:nbn:de:hbz:294-57631
DOI:https://doi.org/10.3390/membranes4030565
Parent Title (English):Membranes
Document Type:Article
Language:English
Date of Publication (online):2018/06/27
Date of first Publication:2014/08/20
Publishing Institution:Ruhr-Universität Bochum, Universitätsbibliothek
Tag:Open Access Fonds
assembly; endocytosis; kainate receptor; retention; trafficking
Volume:4
Issue:3
First Page:565
Last Page:595
Note:
Article Processing Charge funded by the Deutsche Forschungsgemeinschaft (DFG) and the Open Access Publication Fund of Ruhr-Universität Bochum.
Institutes/Facilities:Lehrstuhl für Biochemie I, Rezeptorbiochemie
Dewey Decimal Classification:Naturwissenschaften und Mathematik / Biowissenschaften, Biologie, Biochemie
open_access (DINI-Set):open_access
faculties:Fakultät für Chemie und Biochemie
Licence (English):License LogoCreative Commons - CC BY-NC-SA 3.0 - Attribution-NonCommercial-ShareAlike 3.0 Unported