Effects of treatment of asymptomatic hyperuricemia on graft survival and mortality in kidney transplant recipients
- \(\textbf{Background:}\) Hyperuricemia is very common after renal transplantation. It is associated with an increased risk of cardiovascular events and graft loss. To date, however, treatment is only recommended in symptomatic disease. \(\textbf{Material/Methods:}\) We included 503 adult patients who underwent kidney transplantation at the Charité-Universitätsmedizin Berlin in this retrospective study. Patients were followed up for up to 120 months. All-cause mortality, graft survival, changes in level of serum uric acid (SUA), and estimated glomerular filtration rate (eGFR) were analyzed. \(\textbf{Results:}\) At 12 months post-transplantation, 225 patients had a serum uric acid (SUA) level >7 mg/dl: 52 patients were treated with allopurinol, 37 with benzbromarone, and 136 patients received no medication for hyperuricemia (control). At 12 months, eGFR did not differ between groups (p=0.15) but treated patients had higher SUA levels (p<0.001) compared to the control group. SUA-lowering treatment was associated with a lower risk of allcause mortality (p=0.013) and graft loss (p=0.014) compared to controls. At 120 months, patients in the treatment group had lower SUA levels (p=0.001) and higher eGFR (p<0.001) compared to the control group. \(\textbf{Conclusions:}\) Treatment of asymptomatic hyperuricemia was associated with a substantial benefit in patient and graft survival.
Author: | Nikolaos PagonasGND, Samad KorGND, Felix Sebastian SeibertORCiDGND, Arnd GieseGND, Walter ZidekGND, Petra ReinkeGND, Nina BabelORCiDGND, Frederic BauerGND, Timm WesthoffORCiDGND |
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URN: | urn:nbn:de:hbz:294-57769 |
DOI: | https://doi.org/10.12659/AOT.896821 |
Parent Title (English): | Annals of transplantation |
Document Type: | Article |
Language: | English |
Date of Publication (online): | 2018/06/28 |
Date of first Publication: | 2016/06/07 |
Publishing Institution: | Ruhr-Universität Bochum, Universitätsbibliothek |
Tag: | Open Access Fonds Graft Survival; Hyperuricemia; Kidney Transplantation |
Volume: | 21 |
Issue: | 1 |
First Page: | 350 |
Last Page: | 359 |
Note: | Article Processing Charge funded by the Open Access Publication Fund of Ruhr-Universität Bochum. |
Institutes/Facilities: | Marienhospital Herne, Medizinische Klinik I |
Dewey Decimal Classification: | Technik, Medizin, angewandte Wissenschaften / Medizin, Gesundheit |
open_access (DINI-Set): | open_access |
faculties: | Medizinische Fakultät |
Licence (English): | Creative Commons - CC BY-NC-ND 4.0 - Attribution-NonCommercial-NoDerivatives 4.0 International |