Intraperitoneal cisplatin and doxorubicin as maintenance chemotherapy for unresectable ovarian cancer
- \(\textbf {Background:}\) Primary advanced, unresectable ovarian cancer (OC) is treated with palliative systemic chemotherapy. Intraperitoneal chemotherapy may be an alternative local maintenance therapy. \(\textbf {Case presentation:}\) A 75 year old woman with laparoscopically and histologically confirmed unresectable OC was treated with 13 cycles of intraperitoneal cisplatin \(7.5 mg/m^{2}\) and doxorubicin \(1.5 mg/m^{2}\) over 2 years using laparoscopic pressurized intraperitoneal aerosol chemotherapy (PIPAC). Objective tumor response (tumor regression on histology, stable disease on repeated video-laparoscopy and peritoneal carcinomatosis index) was noted. No Common Terminology Criteria for Adverse Events (CTCAE) > grade 3 were observed. EORTC QLQ-C30 quality of life measurements were stable throughout the therapy. \(\textbf {Conclusions:}\) Repeated intraperitoneal chemotherapy with cisplatin and doxorubicin applied as PIPAC may be an effective maintenance treatment in women with primary advanced, unresectable OC.
| Author: | Clemens TempferORCiDGND, Franziska HartmannGND, Ziad HilalGND, Günther RezniczekORCiDGND |
|---|---|
| URN: | urn:nbn:de:hbz:294-59009 |
| DOI: | https://doi.org/10.1186/s12885-016-3004-8 |
| Parent Title (English): | BMC cancer |
| Subtitle (English): | a case report |
| Document Type: | Article |
| Language: | English |
| Date of Publication (online): | 2018/07/11 |
| Date of first Publication: | 2017/01/06 |
| Publishing Institution: | Ruhr-Universität Bochum, Universitätsbibliothek |
| Tag: | Open Access Fonds Adverse effects; Antineoplastic agents; Intraperitoneal chemotherapy; Maintenance; Ovarian cancer; PIPAC; Peritoneal carcinomatosis; Quality of life |
| Volume: | 17 |
| Issue: | 1 |
| First Page: | 26-1 |
| Last Page: | 26-6 |
| Note: | Article Processing Charge funded by the Deutsche Forschungsgemeinschaft (DFG) and the Open Access Publication Fund of Ruhr-Universität Bochum. |
| Institutes/Facilities: | Marienhospital Herne, Klinik für Frauenheilkunde und Geburtshilfe |
| Dewey Decimal Classification: | Technik, Medizin, angewandte Wissenschaften / Medizin, Gesundheit |
| open_access (DINI-Set): | open_access |
| faculties: | Medizinische Fakultät |
| Licence (English): |  Creative Commons - CC BY 4.0 - Attribution 4.0 International |
