Tenascins in retinal and optic nerve neurodegeneration

  • Tenascins represent key constituents of the extracellular matrix (ECM) with major impact on central nervous system (CNS) development. In this regard, several studies indicate that they play a crucial role in axonal growth and guidance, synaptogenesis and boundary formation. These functions are not only important during development, but also for regeneration under several pathological conditions. Additionally, tenascin-C (Tnc) represents a key modulator of the immune system and inflammatory processes. In the present review article, we focus on the function of Tnc and tenascin-R (Tnr) in the diseased CNS, specifically after retinal and optic nerve damage and degeneration. We summarize the current view on both tenascins in diseases such as glaucoma, retinal ischemia, age-related macular degeneration (AMD) or diabetic retinopathy. In this context, we discuss their expression profile, possible functional relevance, remodeling of the interacting matrisome and tenascin receptors, especially under pathological conditions.

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Metadaten
Author:Jacqueline ReinhardORCiDGND, Lars RollGND, Andreas FaissnerORCiDGND
URN:urn:nbn:de:hbz:294-59689
DOI:https://doi.org/10.3389/fnint.2017.00030
Parent Title (English):Frontiers in integrative neuroscience
Document Type:Article
Language:English
Date of Publication (online):2018/07/18
Date of first Publication:2017/10/23
Publishing Institution:Ruhr-Universität Bochum, Universitätsbibliothek
Tag:Open Access Fonds
extracellular matrix; glaucoma; glycoprotein; neurodegeneration; optic nerve; retina; tenascin-C; tenascin-R
Volume:11
First Page:30-1
Last Page:30-13
Note:
Article Processing Charge funded by the Deutsche Forschungsgemeinschaft (DFG) and the Open Access Publication Fund of Ruhr-Universität Bochum.
Institutes/Facilities:Lehrstuhl für Zellmorphologie und Molekulare Neurobiologie
Dewey Decimal Classification:Naturwissenschaften und Mathematik / Biowissenschaften, Biologie, Biochemie
open_access (DINI-Set):open_access
faculties:Fakultät für Biologie und Biotechnologie
Licence (English):License LogoCreative Commons - CC BY 4.0 - Attribution 4.0 International