How to find RNA thermometers
- Temperature is one of the decisive signals that a mammalian pathogen has entered its warm-blooded host. Among the many ways to register temperature changes, bacteria often use temperature-modulated structures in the untranslated region of mRNAs. In this article, we describe how such RNA thermometers (RNATs) have been discovered one by one upstream of heat shock and virulence genes in the past, and how next-generation sequencing approaches are able to reveal novel temperature-responsive RNA structures on a global scale.
| Author: | Francesco RighettiGND, Franz NarberhausORCiDGND |
|---|---|
| URN: | urn:nbn:de:hbz:294-69691 |
| DOI: | https://doi.org/10.3389/fcimb.2014.00132 |
| Parent Title (English): | Frontiers in cellular and infection microbiology |
| Publisher: | Frontiers Media |
| Place of publication: | Lausanne |
| Document Type: | Article |
| Language: | English |
| Date of Publication (online): | 2020/02/12 |
| Date of first Publication: | 2014/09/18 |
| Publishing Institution: | Ruhr-Universität Bochum, Universitätsbibliothek |
| Tag: | RNA structure; heat shock; next-generation sequencing; regulatory RNA; virulence |
| Volume: | 4 |
| First Page: | 132-1 |
| Last Page: | 132-6 |
| Institutes/Facilities: | Lehrstuhl für Biologie der Mikroorganismen |
| Research Department Plasmas with Complex Interactions | |
| Protein Research Department | |
| Research Department Solvation Science | |
| open_access (DINI-Set): | open_access |
| faculties: | Fakultät für Biologie und Biotechnologie |
| Licence (English): |  Creative Commons - CC BY 4.0 - Attribution 4.0 International |
