The DA antagonist tiapride impairs context-related extinction learning in a novel context without affecting renewal
- Renewal describes the recovery of an extinguished response if recall is tested in a context different from the extinction context. Behavioral studies demonstrated that attention to relevant context strengthens renewal. Neurotransmitters mediating attention and learning such as the dopaminergic (DA) system presumably modulate extinction learning and renewal. However, the role of DA for non-fear-based extinction learning and renewal in humans has not yet been investigated. This fMRI study investigated effects of DA-antagonism upon context-related extinction in a predictive learning task in which extinction occurred either in a novel (ABA) or an unchanged (AAA) context. The tiapride-treated group (TIA) showed significantly impaired ABA extinction learning and a significant within-group difference between ABA and AAA extinction, compared to placebo (PLAC). Groups did not differ in their level of ABA renewal. In ABA extinction, TIA showed reduced activation in dlPFC and OFC, hippocampus, and temporal regions. Across groups, activation in PFC and hippocampus correlated negatively with ABA extinction errors. Results suggest that in context-related extinction learning DA in PFC and hippocampus is involved in readjusting the cue-outcome relationship in the presence of a novel context. However, relating context to the appropriate association during recall does not appear to rely exclusively on DA signaling.
Author: | Silke LissekORCiDGND, Benjamin GlaubitzGND, Oliver T. WolfORCiDGND, Martin TegenthoffGND |
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URN: | urn:nbn:de:hbz:294-69936 |
DOI: | https://doi.org/10.3389/fnbeh.2015.00238 |
Parent Title (English): | Frontiers in behavioral neuroscience |
Publisher: | Frontiers Research Foundation |
Place of publication: | Lausanne |
Document Type: | Article |
Language: | English |
Date of Publication (online): | 2020/02/14 |
Date of first Publication: | 2015/09/03 |
Publishing Institution: | Ruhr-Universität Bochum, Universitätsbibliothek |
Tag: | context-related extinction learning; dopamine; fMRI; hippocampus; prefrontal cortex; renewal effect; tiapride |
Volume: | 9 |
First Page: | 238-1 |
Last Page: | 238-13 |
Institutes/Facilities: | Berufsgenossenschaftliches Universitätsklinikum Bergmannsheil, Neurologische Universitätsklinik und Poliklinik |
Sonderforschungsbereich 1280, A08 - Strukturelle, prozess- und kontextbezogene Faktoren die den Renewal-Effekt der Extinktion vermitteln | |
open_access (DINI-Set): | open_access |
Licence (English): | Creative Commons - CC BY 4.0 - Attribution 4.0 International |