Regulation of the tumor-suppressor BECLIN 1 by distinct ubiquitination cascades
- Autophagy contributes to cellular homeostasis through the degradation of various intracellular targets such as proteins, organelles and microbes. This relates autophagy to various diseases such as infections, neurodegenerative diseases and cancer. A central component of the autophagy machinery is the class III phosphatidylinositol 3-kinase (PI3K-III) complex, which generates the signaling lipid phosphatidylinositol 3-phosphate (PtdIns3P). The catalytic subunit of this complex is the lipid-kinase VPS34, which associates with the membrane-targeting factor VPS15 as well as the multivalent adaptor protein BECLIN 1. A growing list of regulatory proteins binds to BECLIN 1 and modulates the activity of the PI3K-III complex. Here we discuss the regulation of BECLIN 1 by several different types of ubiquitination, resulting in distinct polyubiquitin chain linkages catalyzed by a set of E3 ligases. This contribution is part of the Special Issue "Ubiquitin System".
| Author: | Fahd BoutoujaGND, Rebecca BrinkmeierGND, Thomas MastalskiGND, Fouzi El MagraouiGND, Harald W. PlattaGND |
|---|---|
| URN: | urn:nbn:de:hbz:294-70823 |
| DOI: | https://doi.org/10.3390/ijms18122541 |
| Parent Title (English): | International journal of molecular sciences |
| Publisher: | MDPI |
| Place of publication: | Lausanne |
| Document Type: | Article |
| Language: | English |
| Date of Publication (online): | 2020/03/30 |
| Date of first Publication: | 2017/11/27 |
| Publishing Institution: | Ruhr-Universität Bochum, Universitätsbibliothek |
| Tag: | AMBRA 1; BECLIN 1; VPS34; autophagy; tumor suppressor; ubiquitin |
| Volume: | 18 |
| Issue: | 12, Article 2541 |
| First Page: | 2541-1 |
| Last Page: | 2541-21 |
| Institutes/Facilities: | Institut für Biochemie und Pathobiochemie, Abteilung für Systembiochemie, Arbeitsgruppe Biochemie Intrazellulärer Transportprozesse |
| open_access (DINI-Set): | open_access |
| faculties: | Medizinische Fakultät |
| Licence (English): |  Creative Commons - CC BY 4.0 - Attribution 4.0 International |
