A robust \(\textit {in vivo}\)-like persistent firing supported by a hybrid of intracellular and synaptic mechanisms

  • Persistent firing is believed to support short-term information retention in the brain. Established hypotheses make use of the recurrent synaptic connectivity to support persistent firing. However, this mechanism is known to suffer from a lack of robustness. On the other hand, persistent firing can be supported by an intrinsic cellular mechanism in multiple brain areas. However, the consequences of having both the intrinsic and the synaptic mechanisms (a hybrid model) on persistent firing remain largely unknown. The goal of this study is to investigate whether a hybrid neural network model with these two mechanisms has advantages over a conventional recurrent network based model. Our computer simulations were based on in vitro recordings obtained from hippocampal CA3 pyramidal cells under cholinergic receptor activation. Calcium activated non-specific cationic (CAN) current supported persistent firing in the Hodgkin-Huxley style cellular models. Our results suggest that the hybrid model supports persistent firing within a physiological frequency range over a wide range of different parameters, eliminating parameter sensitivity issues generally recognized in network based persistent firing. In addition, persistent firing in the hybrid model is substantially more robust against distracting inputs, can coexist with theta frequency oscillations, and supports pattern completion.

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Metadaten
Author:Arthur JochemsGND, Motoharu YoshidaGND
URN:urn:nbn:de:hbz:294-73358
DOI:https://doi.org/10.1371/journal.pone.0123799
Parent Title (English):PLoS ONE
Publisher:Public Library of Science
Place of publication:San Francisco
Document Type:Article
Language:English
Date of Publication (online):2020/07/15
Date of first Publication:2015/04/22
Publishing Institution:Ruhr-Universität Bochum, Universitätsbibliothek
Volume:10
Issue:4, Artikel e0123799
First Page:e0123799-1
Last Page:e0123799-22
Note:
Korrektur zum Artikel:

3 Jun 2015: The PLOS ONE Staff (2015) Correction: A Robust In Vivo-Like Persistent Firing Supported by a Hybrid of Intracellular and Synaptic Mechanisms. PLOS ONE 10(6): e0130237.
https://doi.org/10.1371/journal.pone.0130237
Institutes/Facilities:Mercator Forschergruppe "Strukturen des Gedächtnisses"
open_access (DINI-Set):open_access
faculties:Fakultät für Psychologie
International Graduate School of Neuroscience (IGSN)
Licence (English):License LogoCreative Commons - CC BY 4.0 - Attribution 4.0 International