Risky decision-making following prefrontal D1 receptor manipulation
- The prefrontal dopamine D1 receptor (D1R) is involved in cognitive processes. Viral overexpression of this receptor in rats further increases the reward-related behaviors and even its termination induces anhedonia and helplessness. In this study, we investigated the risky decision-making during D1R overexpression and its termination. Rats conducted the rodent version of the Iowa gambling task daily. In addition, the methyl CpG–binding protein-2 (MeCP2), one regulator connecting the dopaminergic system, cognitive processes, and mood-related behavior, was investigated after completion of the behavioral tasks. D1R overexpressing subjects exhibited maladaptive risky decision-making and risky decisions returned to control levels following termination of D1R overexpression; however, after termination, animals earned less reward compared to control subjects. In this phase, MeCP2-positive cells were elevated in the right amygdala. Our results extend the previously reported behavioral changes in the D1R-manipulated animal model to increased risk-taking and revealed differential MeCP2 expression adding further evidence for a bipolar disorder-like phenotype of this model.
Author: | Dominik K. E. BeyerGND, Lisa HornGND, Nadine KlinkerGND, Nadja FreundORCiDGND |
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URN: | urn:nbn:de:hbz:294-89950 |
DOI: | https://doi.org/10.1515/tnsci-2020-0187 |
Parent Title (English): | Translational neuroscience |
Publisher: | De Gruyter |
Place of publication: | Berlin |
Document Type: | Article |
Language: | English |
Date of Publication (online): | 2022/05/25 |
Date of first Publication: | 2021/11/03 |
Publishing Institution: | Ruhr-Universität Bochum, Universitätsbibliothek |
Tag: | Open Access Fonds Iowa gambling task; bipolar disorder; lentivirus; mania; rat |
Volume: | 12 |
Issue: | 1 |
First Page: | 432 |
Last Page: | 443 |
Note: | Article Processing Charge funded by the Open Access Publication Fund of Ruhr-Universität Bochum. |
Institutes/Facilities: | LWL-Universitätsklinikum Bochum, Klinik für Psychiatrie, Psychotherapie und Präventivmedizin, Klinik für experimentelle und molekulare Psychiatrie |
Dewey Decimal Classification: | Technik, Medizin, angewandte Wissenschaften / Medizin, Gesundheit |
open_access (DINI-Set): | open_access |
Licence (English): | Creative Commons - CC BY 4.0 - Attribution 4.0 International |