Caucasians with acral lentiginous melanoma have the same outcome as patients with stage- and limb-matched superficial spreading melanoma
- \(\bf Purpose\) Acral lentiginous melanoma (ALM), a relatively rare subtype of cutaneous melanoma, has been reported to have a worse prognosis than other melanomas. We aimed to assess clinical findings in Caucasian ALM patients and compare the data with a matched cohort of superficial spreading melanoma (SSM) patients. \(\bf Methods\) We studied 63 patients with ALM and 63 randomly stage- and limb-matched patients with SSM (non-ALM). In both cohorts, guideline-adjusted diagnosis, treatment and follow-up were performed. \(\bf Results\) We did not observe differences in prognostic factors (e.g., tumor thickness, ulceration) between the two cohorts. Both in ALM and non-ALM patients positive sentinel lymph node was a significant independent predictor for disease relapse and melanoma-specific death. However, disease relapse and melanoma-specific death rates did not significantly differ between ALM and non-ALM patients. An overall 5-year melanoma-specific survival of 82.5% and 81% was observed in ALM and non-ALM patients, respectively. \(\bf Conclusions\) Our data confirm that patients with ALM have no worse outcome than non-ALM patients when correcting for significant prognostic factors. Hence, the reportedly high rates of fatal ALM cases should not be ascribed to pathobiological differences between ALM and non-ALM but are most likely are a consequence of a delay in diagnosis and thus advanced stage of ALM.
Author: | Laura SusokGND, Thilo GambichlerORCiDGND |
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URN: | urn:nbn:de:hbz:294-97841 |
DOI: | https://doi.org/10.1007/s00432-021-03630-6 |
Parent Title (English): | Journal of cancer research and clinical oncology |
Publisher: | Springer |
Place of publication: | Berlin |
Document Type: | Article |
Language: | English |
Date of Publication (online): | 2023/04/06 |
Date of first Publication: | 2021/04/15 |
Publishing Institution: | Ruhr-Universität Bochum, Universitätsbibliothek |
Tag: | Acral lentiginous melanoma; Overall survival; Progosis; Superficial spreading melanoma |
Volume: | 148 |
First Page: | 497 |
Last Page: | 502 |
Note: | Dieser Beitrag ist auf Grund des DEAL-Springer-Vertrages frei zugänglich. |
Institutes/Facilities: | Katholisches Klinikum Bochum, Dermatologie, Venerologie und Allergologie |
Dewey Decimal Classification: | Technik, Medizin, angewandte Wissenschaften / Medizin, Gesundheit |
open_access (DINI-Set): | open_access |
Licence (English): | Creative Commons - CC BY 4.0 - Attribution 4.0 International |