Associative learning and extinction of conditioned threat predictors across sensory modalities
- The formation and persistence of negative pain-related expectations by classical conditioning remain incompletely understood. We elucidated behavioural and neural correlates involved in the acquisition and extinction of negative expectations towards different threats across sensory modalities. In two complementary functional magnetic resonance imaging studies in healthy humans, differential conditioning paradigms combined interoceptive visceral pain with somatic pain (study 1) and aversive tone (study 2) as exteroceptive threats. Conditioned responses to interoceptive threat predictors were enhanced in both studies, consistently involving the insula and cingulate cortex. Interoceptive threats had a greater impact on extinction efficacy, resulting in disruption of ongoing extinction (study 1), and selective resurgence of interoceptive CS-US associations after complete extinction (study 2). In the face of multiple threats, we preferentially learn, store, and remember interoceptive danger signals. As key mediators of nocebo effects, conditioned responses may be particularly relevant to clinical conditions involving disturbed interoception and chronic visceral pain.
Author: | Laura Ricarda KoenenGND, Robert Jan PawlikGND, Adriane IcenhourGND, Liubov PetrakovaGND, Katarina ForkmannGND, Nina TheysohnGND, Harald Raimund EnglerORCiDGND, Sigrid ElsenbruchORCiDGND |
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URN: | urn:nbn:de:hbz:294-98062 |
DOI: | https://doi.org/10.1038/s42003-021-02008-1 |
Parent Title (English): | Communications biology |
Publisher: | Springer Nature |
Place of publication: | London |
Document Type: | Article |
Language: | English |
Date of Publication (online): | 2023/04/12 |
Date of first Publication: | 2021/05/11 |
Publishing Institution: | Ruhr-Universität Bochum, Universitätsbibliothek |
Volume: | 4 |
Issue: | Article 553 |
First Page: | 553-1 |
Last Page: | 553-17 |
Note: | Dieser Beitrag ist auf Grund des DEAL-Springer-Vertrages frei zugänglich. |
Note: | A Correction to this paper has been published: https://doi.org/10.1038/s42003-021-02542-y |
Institutes/Facilities: | Institut für Medizinische Psychologie und Medizinische Soziologie |
Medizinische Fakultät, Abteilung für Medizinische Psychologie und Medizinische Soziologie | |
Dewey Decimal Classification: | Technik, Medizin, angewandte Wissenschaften / Medizin, Gesundheit |
open_access (DINI-Set): | open_access |
faculties: | Medizinische Fakultät |
Licence (English): | Creative Commons - CC BY 4.0 - Attribution 4.0 International |