Bipolar chronobiology in men and mice
- In patients with bipolar disorder, we do not only see a cycling of mood episodes, but also a shift in circadian rhythm. In the present overview, the circadian rhythm, the "internal clock", and their disruptions are briefly described. In addition, influences on circadian rhythms such as sleep, genetics, and environment are discussed. This description is conducted with a translational focus covering human patients as well as animal models. Concluding the current knowledge on chronobiology and bipolar disorder, implications for specificity and the course of bipolar disorder and treatment options are given at the end of this article. Taken together, circadian rhythm disruption and bipolar disorder are strongly correlated; the exact causation, however, is still unclear.
| Author: | Nadja FreundORCiDGND, Ida Sibylle HaußleiterORCiDGND |
|---|---|
| URN: | urn:nbn:de:hbz:294-105930 |
| DOI: | https://doi.org/10.3390/brainsci13050738 |
| Parent Title (English): | Brain sciences |
| Subtitle (English): | a narrative review |
| Publisher: | MDPI |
| Place of publication: | Basel |
| Document Type: | Article |
| Language: | English |
| Date of Publication (online): | 2024/01/11 |
| Date of first Publication: | 2023/04/29 |
| Publishing Institution: | Ruhr-Universität Bochum, Universitätsbibliothek |
| Tag: | Open Access Fonds circadian; sleep; translational |
| Volume: | 13 |
| Issue: | 5, Article 738 |
| First Page: | 738-1 |
| Last Page: | 738-11 |
| Note: | Article Processing Charge funded by the Deutsche Forschungsgemeinschaft (DFG) and the Open Access Publication Fund of Ruhr-Universität Bochum. |
| Institutes/Facilities: | LWL-Universitätsklinikum Bochum, Klinik für Psychiatrie, Psychotherapie und Präventivmedizin |
| Dewey Decimal Classification: | Technik, Medizin, angewandte Wissenschaften / Medizin, Gesundheit |
| open_access (DINI-Set): | open_access |
| Licence (English): |  Creative Commons - CC BY 4.0 - Attribution 4.0 International |
