Computational analysis of the influence of drusen growth on the morphology of RPE due to Age-related Macular Degeneration
- Age-related macular degeneration (AMD) is a disease that affects the macular region of the outer retina. AMD is characterized by the presence of large extracellular debris called drusen between the Bruch's Membrane (BrM) in the choroid and the retinal pigment epithelium (RPE) in the outer retina. An important feature of AMD is the degenerative changes in the RPE and the photoreceptors that leads to the deterioration and loss of central vision. In this contribution, the effect of drusen size on the morphological changes in the RPE, BrM and photoreceptors are investigated using the cellular potts model (CPM) and machine learning. Numerical simulation of the influence of drusen growth and its effect on the morphology of the outer retinal layers of the macula is presented and the implications for AMD progression discussed.
| Author: | Vijaya HollaORCiDGND, Jithender J. TimothyORCiDGND, Günther MeschkeORCiDGND |
|---|---|
| URN: | urn:nbn:de:hbz:294-110190 |
| DOI: | https://doi.org/10.1002/pamm.202000298 |
| Parent Title (English): | Proceedings in applied mathematics & mechanics |
| Publisher: | Wiley |
| Place of publication: | Weinheim |
| Document Type: | Article |
| Language: | English |
| Date of Publication (online): | 2024/03/08 |
| Date of first Publication: | 2021/01/25 |
| Publishing Institution: | Ruhr-Universität Bochum, Universitätsbibliothek |
| Volume: | 20 |
| Issue: | 1, Artikel e202000298 |
| First Page: | e202000298-1 |
| Last Page: | e202000298-3 |
| Note: | Dieser Beitrag ist auf Grund des DEAL-Wiley-Vertrages frei zugänglich. |
| Institutes/Facilities: | Lehrstuhl für Statik und Dynamik |
| Dewey Decimal Classification: | Technik, Medizin, angewandte Wissenschaften / Ingenieurbau, Umwelttechnik |
| open_access (DINI-Set): | open_access |
| faculties: | Fakultät für Bau- und Umweltingenieurwissenschaften |
| Licence (English): |  Creative Commons - CC BY 4.0 - Attribution 4.0 International |
